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KMID : 0191120130280020268
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Journal of Korean Medical Science
2013 Volume.28 No. 2 p.268 ~ p.273
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Lysophosphatidylcholine, Oxidized Low-Density Lipoprotein and Cardiovascular Disease in Korean Hemodialysis Patients: Analysis at 5 Years of Follow-up
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Lee Young-Ki
Lee Dong-Hun
Kim Jin-Kyung
Park Min-Jeong
Yan Ji-Jing
Song Dong-Keun
Nosratola D Vaziri
Noh Jung-Woo
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Abstract
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Although oxidized low-density lipoprotein (LDL) and lysophosphatidylcholine (LPC) have been proposed as important mediators of the atherosclerosis, the long-term contribution to the risk of cardiovascular disease (CVD) in hemodialysis patients has not been evaluated. This study investigated the relation between oxidized LDL and LPC levels with long term risk of CVD. Plasma oxidized LDL and LPC levels were determined in 69 Korean hemodialysis patients as a prospective observational study for 5 yr. During the observation period, 18 cardiovascular events (26.1%) occurred including 6 deaths among the hemodialysis patients. The low LPC level group (≤ 254 μM/L, median value) had much more increased risk of CVD compared to the high LPC level group (> 254 μM/L) (P = 0.01). However, serum levels of oxidized LDL were not significantly different between groups with and without CVD. In adjusted Cox analysis, previous CVD, (hazard ratio [HR], 5.68; 95% confidence interval [CI], 1.94-16.63, P = 0.002) and low LPC level (HR, 3.45; 95% CI, 1.04-11.42, P = 0.04) were significant independent risk factors for development of CVD. It is suggested that low LPC, but not oxidized LDL, is associated with increased risk of CVD among a group of Korean hemodialysis patients.
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KEYWORD
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Renal Dialysis, Cardiovascular Disease, Lipoproteins, Oxidized LDL, Lysophosphatidylcholines
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